Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327602
Type: Artigo
Title: Lymphocyte Immunotherapy In The Treatment Of Recurrent Miscarriage: Systematic Review And Meta-analysis
Author: Cavalcante
Marcelo Borges; Sarno
Manoel; Araujo Junior
Edward; Costa
Fabricio Da Silva; Barini
Ricardo
Abstract: Purpose Recurrent miscarriage (RM) affects up to 2-3% of couples of reproductive age. There are several causes for this condition, including immunologic. The embryo is considered an allograft, subject to the rejection mechanisms of the maternal immune system. Immunotherapy involving immunization with lymphocytes is considered in cases of idiopathic RM. However, there is still no consensus regarding the efficacy and safety of this therapy. Methods This systematic review and meta-analysis evaluated the data available in the literature regarding the efficacy and safety of the use of immunotherapy with lymphocytes in couples with history of RM. Searches in PubMed/Medline, SCOPUS, and Cochrane Library databases were conducted, using the following keywords: ``recurrent miscarriage,'' ``lymphocyte immunotherapy,'' and ``meta-analysis.'' Statistical analyses were performed using Review Manager 5.3 (RevMan), version 5.3. Results Six published meta-analysis were retrieved; two found no improvements in the rate of live births after the use of immunization with lymphocytes in the treatment of RM, and four found a beneficial effect of the use of immunotherapy with lymphocytes in cases of RM, with significant improvements in the rate of live births. Conclusion Data available in the literature supports the efficacy and safety of immunotherapy with lymphocytes in cases of RM without an identified cause.
Subject: Lymphocyte Immunotherapy
Recurrent
Miscarriage
Systematic Review
Editor: Springer Heidelberg
Heidelberg
Citation: Archives Of Gynecology And Obstetrics. Springer Heidelberg, v. 295, p. 511 - 518, 2017.
Rights: fechado
Identifier DOI: 10.1007/s00404-016-4270-z
Address: https://link-springer-com.ez88.periodicos.capes.gov.br/article/10.1007%2Fs00404-016-4270-z
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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