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Type: Artigo
Title: Ferritin Levels And Risk Of Heart Failure-the Atherosclerosis Sisk In Communities Study
Author: Silvestre
Odilson M.; Goncalves
Alexandra; Nadruz
Jr.; Claggett
Brian; Couper
David; Eckfeldt
John H.; Pankow
James S.; Anker
Stefan D.; Solomon
Scott D.
Abstract: Severe iron overload is associated with cardiac damage, while iron deficiency has been related to worse outcomes in subjects with heart failure (HF). This study investigated the relationship between ferritin, a marker of iron status, and the incidence of HF in a community-based cohort. Methods and results We examined 1063 participants who were free of heart failure from the Atherosclerosis Risk in Communities (ARIC) Study in whom ferritin serum levels were measured at baseline (1987-1989). The participants (mean age 52.7 +/- 5.5 years, 62% women), were categorized in low (<30 ng/mL; n = 153), normal (30-200 ng/mL in women and 30-300 ng/mL in men; n = 663), and high (>200 ng/mL in women and >300 ng/mL in men; n = 247) ferritin levels. Multivariable Cox proportional hazards models were used to evaluate the relationship between ferritin and incident HF. After 21 +/- 4.6 years of follow-up, HF occurred in 144 (13.5%) participants. When compared with participants with normal ferritin levels, participants with low ferritin levels had a higher risk of HF [hazard ratio (HR)= 2.24, 95% confidence interval (CI) 1.15-4.35; P = 0.02] as did those with high ferritin levels (HR = 1.81, 95% CI 1.01-3.25; P = 0.04), after adjusting for potential confounders. Notably, low ferritin levels remained associated with incident HF even after excluding subjects with anaemia (HR= 2.28, 95% CI 1.11-4.68; P = 0.03). Conclusion Derangements in iron metabolism, either low or high ferritin serum levels, were associated with higher risk of incident HF in a general population, even without concurrent anaemia. These findings suggest that iron imbalance might play a role in the development of HF.
Subject: Heart Failure
Iron Deficiency
Iron Overload
Editor: Wiley-Blackwell
Rights: fechado
Identifier DOI: 10.1002/ejhf.701
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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