Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327559
Type: Artigo
Title: Alternative Mannosylation Method For Nanomaterials: Application To Oxidized Debris-free Multiwalled Carbon Nanotubes
Author: de Sousa
Marcelo; Teodoro Martinez
Diego Stefani; Alves
Oswaldo Luiz
Abstract: Mannosylation is a method commonly used to deliver nanomaterials to specific organs and tissues via cellular macrophage uptake. In this work, for the first time, we proposed a method that involves the binding of D-mannose to ethylenediamine to form mannosylated ethylenediamine, which is then coupled to oxidized and purified multiwalled carbon nanotubes. The advantage of this approach is that mannosylated ethylenediamine precipitates in methanol, which greatly facilitates the separation of this product in the synthesis process. Carbon nanotubes were oxidized using concentrated H2SO4 and HNO3 by conventional reflux method. However, during this oxidation process, carbon nanotubes generated carboxylated carbonaceous fragments (oxidation debris). These by-products were removed from the oxidized carbon nanotubes to ensure that the functionalization would occur only on the carbon nanotube surface. The coupling of mannosylated ethylenediamine to debris-free carbon nanotubes was accomplished using n-(3-dimethylaminopropyl)-nethylcarbodiimide and n-hydroxysuccinimide. Deconvoluted N1s spectra obtained from X-ray photoelectron spectroscopy gave binding energies of 399.8 and 401.7 eV, which we attributed to the amide and amine groups, respectively, of carbon nanotubes functionalized with mannosylated ethylenediamine. Deconvoluted O1s spectra showed a binding energy of 532.4 eV, which we suggest is caused by an overlap in the binding energies of the aliphatic CO groups of D-mannose and the O=C group of the amide bond. The functionalization degree was approximately 3.4 %, according to the thermogravimetric analysis. Scanning electron microscopy demonstrated that an extended carbon nanotube morphology was preserved following the oxidation, purification, and functionalization steps.
Subject: Nanotubes
Mannose
Mannosylated Ethylenediamine
Functionalization
Debris
Binding Energy
Nanostructured Catalysts
Editor: Springer
Dordrecht
Citation: Journal Of Nanoparticle Research. Springer, v. 18, p. , 2016.
Rights: fechado
Identifier DOI: 10.1007/s11051-016-3399-9
Address: https://link-springer-com.ez88.periodicos.capes.gov.br/article/10.1007%2Fs11051-016-3399-9
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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