Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327556
Type: Artigo
Title: Essential Oil From Fruit Of Xylopia Langsdorffiana: Antitumour Activity And Toxicity
Author: Gomes Moura
Ana Paula; Beltrao
Daiene Martins; Lima Rodrigues Pita
Joao Carlos; Xavier
Aline Lira; Brito
Monalisa Taveira; Gomes de Sousa
Tatyanna Kelvia; Batista
Leonia Maria; de Carvalho
Joao Ernesto; Tasca Gois Ruiz
Ana Lucia; Torre
Adriana Della; Duarte
Marcelo Cavalcante; Tavares
Josean Fechine; da Silva
Marcelo Sobral; Sobral
Marianna Vieira
Abstract: The genus Xylopia L. (Annonaceae) includes aromatic plants that have both nutritional and medicinal uses. Essential oils of Xylopia species have antitumour effects. However, the efficacy of the essential oil from the fruit of Xylopia langsdorffiana St. Hil & Tul. (EOX) has not been examined. Objective: EOX was evaluated to determine its chemical composition, antitumour activity and toxicity. Materials and methods: EOX was obtained from fresh fruits of X. langsdorffiana subjected to hydrodistillation, and gas chromatography-mass spectrometry was used to characterize the chemical composition of EOX. The toxicity of EOX was evaluated using haemolysis, acute toxicity and micronucleus assays. The in vitro antitumour activity of EOX was investigated using the sulforhodamine B assay. The sarcoma 180 murine tumour model was used to evaluate the in vivo antitumour activity and toxicity of EOX (50 and 100mg/kg) after 7 d of treatment. Results: The major components of EOX were a-pinene (34.57%) and limonene (31.75%). The HC50 (concentration producing 50% haemolysis) was 293.6 mu g/ml. EOX showed greater selectivity for the leukaemia cell line K562, with total growth inhibition (TGI) (concentration producing TGI) of 1.8 mu g/ml, and for multidrugresistant ovarian tumour cell line NCI/ADR-RES (TGI of 45.4 mu g/ml). The LD50 was approximately 351.09mg/ kg. At doses of 50 and 100 mg/kg, EOX inhibited the in vivo growth of sarcoma 180 by 38.67 and 54.32%, respectively. EOX displayed minor hepatic alterations characteristic of acute hepatitis and induced no genotoxicity. Conclusion: EOX showed in vitro and in vivo antitumour activity and low toxicity, which warrants further pharmacological studies.
Subject: Annonaceae
Cytotoxicity
Genotoxicity
Editor: Taylor & Francis Ltd
Abingdon
Citation: Pharmaceutical Biology . Taylor & Francis Ltd, v. 54, p. 3093 - 3102, 2016.
Rights: fechado
Identifier DOI: 10.1080/13880209.2016.1211154
Address: http://www.tandfonline.com/doi/full/10.1080/13880209.2016.1211154
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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