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|Title:||Enhanced Performance Of A Metal-organic Framework Analogue To Mil-101(cr) Containing Amine Groups For Ibuprofen And Nimesulide Controlled Release|
Irlene M. P.; Carvalho
Marcos A.; Oliveira
Cintia S.; Profirio
Daniel M.; Ferreira
Ricardo B.; Corbi
Pedro P.; Formiga
Andre L. B.
|Abstract:||In order to improve the interaction of MIL-101(Cr) with ibuprofen (IBU) and nimesulide (NMS), its functionalization with NH2 groups was proposed. MIL-101(Cr) showed a good loading capacity of IBU and NMS (850 and 443 mg g(-1), respectively) and released 80% of IBU and 10% and NMS after 8 days. The 10% NH2-MIL-101(Cr) showed a higher loading capacity than MIL-101(Cr) (900 mg g(-1) for IBU and 563 mg g(-1) for NMS) and released lower amounts of IBU (70%) after 6 days and NMS (8%) after 8 days. The results show that the functionalization with NH2 groups improves the interactions between the materials and the drugs, which is of interest in the development of new controlled drug release devices. (C) 2016 Elsevier B.V. All rights reserved.|
|Subject:||Controlled Drug Release|
|Editor:||Elsevier Science BV|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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