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Type: Artigo
Title: Combination Of Fluconazole With Silver Nanoparticles Produced By Fusarium Oxysporum Improves Antifungal Effect Against Planktonic Cells And Biofilm Of Drug-resistant Candida Albicans
Author: Longhi
Carline; Santos
Jussevania Pereira; Morey
Alexandre Tadachi; Marcato
Priscyla Daniely; Duran
Nelson; Pinge-Filho
Phileno; Nakazato
Gerson; Yamada-Ogatta
Sueli Fumie; Yamauchi
Lucy Megumi
Abstract: Silver nanoparticles (AgNPs) have been extensively studied because of their antimicrobial potential. Here, we evaluated the effect of biologically synthesized silver nanoparticles (AgNPbio) alone and in combination with fluconazole (FLC) against planktonic cells and biofilms of FLC-resistant Candida albicans. AgNPbio exhibited a fungicidal effect, with a minimal inhibitory concentration (MIC) and fungicidal concentration ranging from 2.17 to 4.35 mu g/ml. The combination of AgNPbio and FLC reduced the MIC of FLC around 16 to 64 times against planktonic cells of all C. albicans. There was no significant inhibitory effect of AgNPbio on biofilm cells. However, FLC combined with AgNPbio caused a significant dose-dependent decrease in the viability of both initial and mature biofilm. All concentrations of AgNPbio, alone or in combination with FLC, were not cytotoxic to mammalian cells. The results highlight the effectiveness of the combination of AgNPbio with FLC against FLC-resistant C. albicans.
Subject: Fluconazole Resistance
Biological Nanoparticles
Fungicidal Effect
Editor: Oxford Univ Press
Rights: fechado
Identifier DOI: 10.1093/mmy/myv036
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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