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|Title:||Bleeding Patterns Of Hiv-infected Women Using An Etonogestrel-releasing Contraceptive Implant And Efavirenz-based Or Lopinavir/ritonavir-based Antiretroviral Therapy|
Conrado S.; Bahamondes
Maria Valeria; Rocha Prandini
Tatiana R.; Brito
Milena Bastos; Amaral
Silvana Maria; Ferriani
Rui Alberto; Vieira
|Abstract:||The use of progestogen-only contraceptives may cause a change in bleeding pattern, which is a common cause of discontinuation of these methods. Co-administration with some antiretroviral therapies (ART) changes the bioavailability of the etonogestrel (ENG)-releasing contraceptive implant, possibly affecting the bleeding pattern. Bleeding patterns were evaluated in HIV-positive users of the ENG implant co-administered with two common ART regimens.Methods: Forty-five HIV-positive women who wished to use an ENG implant were included in this study: 15 had received zidovudine/lamivudine (AZT/3TC) + lopinavir/ritonavir (LPV/r) for 3 months (LPV/r-based ART group), 15 had received AZT/3TC+efavirenz (EFV) for 3 months (EFV-based ART group), and 15 had not received ART (non-ART group). Bleeding patterns were evaluated at 3 and 6 months after implant placement using a standard bleeding calendar.Results: Amenorrhoea and infrequent bleeding rates were higher in the LPV/r-based ART group (50% and 36%, respectively) than in the other groups (non-ART group, 36% and 29%, respectively; EFV-based ART group, 7% and 14.5%, respectively; p=0.01). The EFV-based ART group more frequently had regular bleeding (71.5%) compared with the other groups (LPV/r-based ART group, 7%; non-ART group, 21%; p=0.01). The proportions of women with frequent and prolonged bleeding were similar (p>0.05) in the three groups.Conclusions: The co-administration of EFV-based or LPV/r-based ART with the ENG implant affected the expected bleeding patterns during use of the implant, although unfavourable bleeding (frequent and prolonged) was not associated with the medications under evaluation.|
|Editor:||Taylor & Francis Ltd|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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