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|Title:||Achieving Regio- And Stereo-control In The Fluorination Of Aziridines Under Acidic Conditions|
Achieving regio- and stereo-control in the fluorination of aziridines under acidic conditions
|Author:||Okoromoba, Otome E.|
Mashuta, Mark S.
Couto, Uenifer R.
Tormena, Cláudio F.
Hammond, Gerald B.
|Abstract:||We developed an efficient fluorination protocol that converts easily accessible aziridines into beta-fluoroamines, which are important motifs in biologically active molecules. In contrast with traditional fluorination approaches, DMPU-HF has shown both higher reactivity and regioselectivity and good functional group tolerance; thus, a wide scope of beta-fluoroamines can now be accessed conveniently. The stereochemical behavior of the ring opening depends on the substitution pattern of the aziridine substrate.|
We developed an efficient fluorination protocol that converts easily accessible aziridines into β-fluoroamines, which are important motifs in biologically active molecules. In contrast with traditional fluorination approaches, DMPU–HF has shown both highe
|Editor:||Royal Society of Chemistry|
|Citation:||Chemical Communications. Royal Soc Chemistry, v. 52, p. 13353 - 13356, 2016.|
|Appears in Collections:||IQ - Artigos e Outros Documentos|
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