Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327478
Type: Artigo
Title: Achieving Regio- And Stereo-control In The Fluorination Of Aziridines Under Acidic Conditions
Achieving regio- and stereo-control in the fluorination of aziridines under acidic conditions
Author: Okoromoba, Otome E.
Li, Zhou
Robertson, Nicole
Mashuta, Mark S.
Couto, Uenifer R.
Tormena, Cláudio F.
Xu, Bo
Hammond, Gerald B.
Abstract: We developed an efficient fluorination protocol that converts easily accessible aziridines into beta-fluoroamines, which are important motifs in biologically active molecules. In contrast with traditional fluorination approaches, DMPU-HF has shown both higher reactivity and regioselectivity and good functional group tolerance; thus, a wide scope of beta-fluoroamines can now be accessed conveniently. The stereochemical behavior of the ring opening depends on the substitution pattern of the aziridine substrate.
We developed an efficient fluorination protocol that converts easily accessible aziridines into β-fluoroamines, which are important motifs in biologically active molecules. In contrast with traditional fluorination approaches, DMPU–HF has shown both highe
Subject: Hydrogen-fluoride
Synthetic Methods
Amines
Reagents
Hydrofluorination
Derivatives
Convenient
Complexes
Catalysis
Alkynes
Aziridina
Fluoração
Country: Reino Unido
Editor: Royal Society of Chemistry
Citation: Chemical Communications. Royal Soc Chemistry, v. 52, p. 13353 - 13356, 2016.
Rights: fechado
Identifier DOI: 10.1039/C6CC07855A
Address: https://pubs.rsc.org/en/Content/ArticleLanding/2016/CC/C6CC07855A#!divAbstract
Date Issue: 2016
Appears in Collections:IQ - Artigos e Outros Documentos

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