Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327359
Type: Artigo
Title: Defining Biological Subsets In Systemic Lupus Erythematosus: Progress Toward Personalized Therapy
Author: Sinicato
Nailu Angelica; Postal
Mariana; Appenzeller
Simone; Niewold
Timothy B.
Abstract: Systemic lupus erythematosus (SLE) is a heterogeneous disease with respect to disease severity, response to treatment, and organ damage, the pathogenesis of which includes immunological mechanisms that are driven by both genetic and environmental factors. There are clear differences in the pathogenesis of SLE between patients of different ancestral backgrounds, including differences in genetic risk factors, immunological parameters, and clinical manifestations. Patients with high and low levels of type I interferon (IFN) in circulation represent one major biological subset within SLE, and these two groups of patients are present in all ancestral backgrounds. Genetic factors, autoantibodies, and levels of other cytokines all differ between high and low IFN patients. This distinction has also been important in predicting response to treatment with anti-type I IFN therapies, providing a precedent in SLE for biological subsets predicting treatment response. This review highlights some recent developments in defining biological subsets of SLE based on disease pathophysiology, and we speculate how this improved knowledge of disease heterogeneity will inform our efforts to personalize therapy in this disease.
Subject: Interferon-alpha Activity
Genome-wide Association
Genetic Susceptibility Loci
Risk Haplotype
African-americans
High Prevalence
Interferon
Sle Patients
Ifn-alpha
Nephritis
Editor: Springer International Publishing Ag
Cham
Rights: fechado
Identifier DOI: 10.1007/s40290-017-0178-6
Address: https://link.springer.com/article/10.1007/s40290-017-0178-6
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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