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Type: Artigo
Title: Physical-chemical Properties Of Furosemide Nanocrystals Developed Using Rotation Revolution Mixer
Author: Barbosa
Savio Fujita; Takatsuka
Takayuki; Tavares
Guilherme Diniz; Barros Araujo
Gabriel Lima; Wang
Hui; Vehring
Reinhard; Lobenberg
Raimar; Bou-Chacra
Nadia Araci
Abstract: Recently, several approaches have been reported to improve the dissolution rate and bioavailability of furosemide, a class IV drug. However, to the best of our knowledge, none of them proposed nanocrystals. In the last decade, nanocrystals successfully addressed solubility issues by increasing surface area and saturation solubility, both leading to an increase in the dissolution rate of poor water soluble drugs. The preparation of furosemide nanocrystals was by a rotation revolution mixer method. Size distribution and morphology were performed using laser diffraction and scanning electron microscopy, respectively. In addition, differential scanning calorimetry, thermogravimetry, X-ray powder diffraction (XRD) and low frequency shift-Raman spectroscopy allowed investigating the thermal properties and crystalline state. Solubility saturation and intrinsic dissolution rate (IDR) studies were conducted. The thermal analysis revealed lower melting range for the nanocrystals comparing to furosemide. Moreover, a slight crystalline structure change to the amorphous state was observed by XRD and confirmed by low frequency shift Raman. The particle size was reduced to 231nm with a polydispersity index of 0.232, a 30-fold reduction from the original powder. Finally, the saturation solubility and IDR showed a significant increase. Furosemide nanocrystals showed potential for development of innovative formulations as an alternative to the commercial products.
Subject: Dissolution Rate
Drug Delivery Systems
High-energy Milling
Poorly Water-soluble Drug
Editor: Taylor & Francis Ltd
Rights: fechado
Identifier DOI: 10.3109/10837450.2015.1063650
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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