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Type: Artigo
Title: Low-level Laser Therapy Induces An Upregulation Of Collagen Gene Expression During The Initial Process Of Bone Healing: A Microarray Analysis
Author: Tim
Carla Roberta; Bossini
Paulo Sergio; Kido
Hueliton Wilian; Malavazi
Iran; Kress
Marcia Regina von Zeska; Carazzolle
Marcelo Falsarella; Renno
Ana Claudia; Parizotto
Nivaldo Antonio
Abstract: This study investigates the histological modifications produced by low level laser therapy (LLLT) on the first day of bone repair, as well as evaluates the LLLT effects on collagen expression on the site of a fracture. Twenty Wistar rats were distributed into a control group (CG) and a laser group (LG). Laser irradiation of Ga-AlAs laser 830 nm, 30 mW, 94 s, 2.8 J was performed in five sessions. Animals were euthanized on day 5 post-surgery. Histopathological analysis showed that LLLT was able to increase deposition of granulation tissue and newly formed bone at the site of the injury. In addition, picrosirius analysis showed that collagen fiber organization in the LG was enhanced compared to CG. Microarray analysis demonstrated that LLLT produced an upregulation type I collagen (COL-I). Immunohistochemical analysis revealed that the subjects that were treated presented a higher immunoexpression of COL-I. Our findings indicated that LLLT improves bone healing by producing a significant increase in the expression of collagen genes. (C) 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Subject: Bone Regeneration
Low Level Laser Therapy
Editor: Spie-Soc Photo-Optical Instrumentation Engineers
Citation: Journal Of Biomedical Optics. Spie-soc Photo-optical Instrumentation Engineers , v. 21, p. , 2016.
Rights: aberto
Identifier DOI: 10.1117/1.JBO.21.8.088001
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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