Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327249
Type: Artigo
Title: Atheroprotective Properties Of Serum Igf-1 In The Carotid And Coronary Territories And Beneficial Role On The Physical Fitness Of The Oldest Old
Author: Cordova
Claudio; Boullosa
Daniel A.; Custodio
Misael R. M.; Quaglia
Luiz A.; Santos
Simone N.; Freitas
Wladimir M.; Sposito
Andrei C.; Nobrega
Otavio T.
Abstract: Our aim was to investigate whether physiological levels of soluble insulin-like growth factor-1 (IGF-1) associate with coronary and carotid atherosclerotic burden and physical fitness in the oldest old by means of a cross-sectional study including 100 community-dwelling individuals with no previous cardiovascular events. Linear correlation was found between IGF-1 and intima-media thickness, number of carotid plaques, and walking speed. Individuals in the upper IGF-1 tertile had smaller right and left intima-media thickness compared with the intermediate and lower tertiles, along with reduced atherosclerotic plaques. Also, walking speed was greater in the upper IGF-1 tertile. On the other hand, a nonlinear correlation was observed between IGF-1 and coronary calcification scores, with the intermediate IGF-1 tertile associated to the lowest scores of calcification and participants with lower circulating levels of IGF-1 showing higher frequency of high-risk morphology plaques. All in all, our report supports a territory-dependent, atherorefractory phenotype in the oldest old carrying middle and/or higher serum levels of IGF-1.
Subject: Carotid Atherosclerosis
Coronary Calcification
Physical Fitness
Risk Factor
Insulin-like Growth Factor-1
Editor: Oxford Univ Press
Cary
Rights: fechado
Identifier DOI: 10.1093/gerona/glv216
Address: https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glv216
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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