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Type: Artigo
Title: Vaginal Inflammation: Association Between Leukocyte Concentration And Levels Of Immune Mediators
Author: Beghini
Joziani; Giraldo
Paulo C.; Eleuterio
Jr.; do Amaral
Rose Luce; Polpeta
Nadia C.; Goncalves
Ana Katherine
Abstract: Problem A wide variety of mediators are involved in inflammatory processes. However, the identity of those participating in vaginal immune responses has not been established. We correlated extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase-8 (MMP-8), hyaluronan (HA), hyaluronidase-1 (Hyal-1), human beta-defensin-2 (hBD2), and neutrophil gelatinase-associated lipocalin (NGAL) concentrations with the extent of leukocyte infiltration into the vagina and suggest their participation in vaginal inflammation. Methods of study Vaginal fluid was obtained from 233 women seen at the outpatient clinic in the Department of Obstetrics and Gynecology at Campinas University, Brazil. The magnitude of vaginal inflammation was determined by the leukocyte count on vaginal smears and categorized as no inflammation (0 leukocytes/field), moderate inflammation (1-4 leukocytes/field), and intense inflammation (>4 leukocytes/field). Concentrations of EMMPRIN, MMP-8, HA, Hyal-1, hBD2, and NGAL were determined in vaginal fluid by ELISA. Results EMMPRIN, MMP-8, HA, hBD2, and NGAL concentration increased with elevated leukocyte numbers (P < 0.05), while Hyal-1 did not. EMMPRIN concentrations were correlated with HA and MMP-8 levels. Conclusion EMMPRIN, MMP-8, HA, b-defensin, and NGAL are elevated in women with vaginal inflammation.
Subject: Beta-defensin
Extracellular Matrix Metalloproteinase Inducer (emmprin)
Matrix Metalloproteinase-8 (mmp-8)
Neutrophil Gelatinase-associated Lipocalin (ngal)
Editor: Wiley-Blackwell
Citation: American Journal Of Reproductive Immunology. Wiley-blackwell, v. 75, p. 126 - 133, 2016.
Rights: fechado
Identifier DOI: 10.1111/aji.12475
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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