Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327045
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt
dc.contributor.authoremailhamartinezco@unal.edu.copt
dc.typeArtigopt
dc.titleIntegrated Extraction Process To Obtain Bioactive Extracts Of Artemisia Annua L. Leaves Using Supercritical Co2, Ethanol And Wateren
dc.contributor.authorMartinez-Correa
dc.contributor.authorHugo A.; Bitencourt
dc.contributor.authorRaphaela G.; Kayano
dc.contributor.authorAna Carolina A. V.; Magalhaes
dc.contributor.authorPedro M.; Costa
dc.contributor.authorFabio T. M.; Cabral
dc.contributor.authorFernando A.
unicamp.authorCabral, Fernando A.] Univ Campinas UNICAMP, Dept Food Engn, BR-13083862 Campinas, SP, Brazilpt_BR
unicamp.authorCosta, Fabio T. M.] Univ Estadual Campinas, Dept Genet Evolut & Bioagents, Inst Biol, Lab Trop Dis Prof Dr Luiz Jacintho da Silva, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.author[Magalhaes, Pedro M.] Univ Campinas UNICAMP, Chem Biol & Agr Pluridisciplinary Res Ctr, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.author.external[Martinez-Correa, Hugo A.] Univ Nacl Colombia, Dept Engn, Cr 32 12-00, Palmira, Colombiapt_BR
unicamp.author.external[Bitencourt, Raphaela G.pt_BR
unicamp.author.external[Kayano, Ana Carolina A. V.pt_BR
dc.subjectArtemisia Annua L.en
dc.subjectSupercritical Extractionen
dc.subjectArtemisininen
dc.subjectAntimalarial Activityen
dc.subjectPhenolic Compoundsen
dc.subjectFlavonoidsen
dc.description.abstractArtemisia annua L. is an herb used in traditional Chinese medicine due to presence of biocompounds with biomedical and pharmaceutical applications. In this work, an integrated process for extraction of bioactive compounds present in A. annua leaves was performed. The process comprised two-step extractions: in the first step supercritical carbon dioxide (scCO(2)) was used as a solvent, and from the solid residue of the supercritical extraction other extracts were obtained (second stage) using ethanol or water as solvents. Single-step extractions using ethanol or water as solvents were also performed for comparison. In all extracts the variables analyzed were overall extraction yield, the content and yield of total phenolic, total flavonoids and artemisinin, as well as antimalarial activity. The supercritical (SC) and ethanolic (E) extracts obtained in a single step showed the highest yields of artemisinin and were very active against Plasmodium falciparum, with IC50 values less than 0.1 mu g mL(.)(-1) On the other hand, the aqueous (SCA) and ethanolic (SCE) extracts from the second extraction step were free of artemisinin, but these extracts contained roughly 90 mg of phenolic compounds per gram of extract, including a high overall yield in the aqueous extract. The volatile fraction (SC-V) obtained from the supercritical extraction consisted mainly of camphor. Therefore, the two-step extraction in two steps proved to be advantageous because the residue of supercritical extraction could be used for obtaining aqueous or ethanolic extracts containing phenolic compounds. (C) 2016 Elsevier B.V. All rights reserved.en
dc.relation.ispartofIndustrial Crops and Productspt
dc.publisherElsevier Science BVen
dc.publisherAmsterdamen
dc.date.issued2017pt
dc.date.monthofcirculationjanpt
dc.identifier.citationIndustrial Crops And Products. Elsevier Science Bv, v. 95, p. 535 - 542, 2017.
dc.language.isoEnglishpt
dc.description.volume95pt
dc.description.initialpage535pt
dc.description.lastpage542pt
dc.rightsfechadopt
dc.sourceWOSpt
dc.identifier.issn0926-6690pt
dc.identifier.eissn1872-633Xpt
dc.identifier.wosidWOS:000390621600061pt
dc.identifier.doi10.1016/j.indcrop.2016.11.007pt
dc.identifier.urlhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0926669016307518?via%3Dihubpt
dc.description.sponsorshipFAPESP [2007/59367-0]
dc.description.sponsorshipCAPES
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.date.available2017-11-13T13:13:25Z-
dc.date.accessioned2017-11-13T13:13:25Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:13:25Z (GMT). No. of bitstreams: 1 000390621600061.pdf: 997178 bytes, checksum: a7b7fac8e38ce155df988548d9a8dfaf (MD5) Previous issue date: 2017en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327045-
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