Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326925
Type: Artigo
Title: Abnormality In Hippocampal Signal Intensity Predicts Atrophy In Patients With Systemic Lupus Erythematosus
Author: Lapa
A. T.; Pedro
T.; Francischinelli
J.; Coan
A. C.; Lavras Costallat
L. T.; Cendes
F.; Appenzeller
S.
Abstract: To quantify signal abnormalities in the hippocampus (Hsig) of patients with systemic lupus erythematosus (SLE) and to determine if Hsig predict hippocampal atrophy (HA) in SLE. Methods We included all SLE patients and healthy age- and sex-matched individuals with two magnetic resonance imaging (MRI) scans performed with a minimum of 1 year interval. All individuals underwent a standardized neuropsychological evaluation. Individual results were converted into standard scores and compared to normative data. SLE patients were additionally assessed for disease activity (SLE Disease Activity Index (SLEDAI)), damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)), and the presence of antiphospholipid antibodies. MRI was performed on an Elscint 2 T scanner and T1 inversion recovery and T2 coronal images were used for analysis. Volumetric (HV) and signal quantification (Hsig) were determined by standardized protocols. Results We included 54 SLE patients (48 women; mean age 32.210.56 years). Hsig were found at study entry in 15 (45.5%) patients. Hsig in the body and tail of non-atrophic hippocampi correlated with progression of volume loss during the follow-up period (r=0.8, p<0.001). The presence of Hsig in the head of atrophic hippocampi correlated with progression of HA (r=0.73, p=0.005) during the same period. No correlation of Hsig and disease activity or prednisone dose was observed. Conclusion HA is frequently observed in SLE patients and volume loss is progressive in a subgroup of patients. The evaluation of Hsig is an easy tool to determine patients that may have progressive hippocampal volume loss and should be followed more closely with MRI and cognitive evaluation.
Subject: Hippocampal Signal Abnormality
Gliosis
Cognitive Impairment
Editor: Sage Publications LTD
London
Rights: fechado
Identifier DOI: 10.1177/0961203316673151
Address: http://journals.sagepub.com/doi/abs/10.1177/0961203316673151
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000399305000009.pdf159.16 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.