Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326919
Type: Artigo
Title: S100 Beta Is Associated With Cognitive Impairment In Childhood-onset Systemic Lupus Erythematosus Patients
Author: Lapa
A. T.; Postal
M.; Sinicato
N. A.; Bellini
B. S.; Fernandes
P. T.; Marini
R.; Appenzeller
S.
Abstract: To investigate serologic S100 beta protein levels in childhood-onset SLE patients (cSLE) and to elucidate their association with disease activity and neuropsychiatric (NP) manifestations. Methods: We included 71 cSLE patients (67 females; median age 18 years; range 9-37 and 53 (47 females; median age of 20 years; range 6-29) age and sex matched healthy controls. Neurological manifestations were analysed according to the American College of Rheumatology (ACR) criteria. Cognitive evaluation was performed in all participants using Wechsler Intelligence Scale for Children (WISC-III) and Wechsler Adult Intelligence Scale (WAIS), according to age, and validated in Portuguese. SLE patients were further assessed for clinical and laboratory SLE manifestations, disease activity (SLE Disease Activity Index (SLEDAI)), damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI)) and current drug exposures. Sera S100 beta protein levels were measured by enzyme-linked immunosorbent assay using commercial kits. Results: The median S100 beta protein level was 116.55 pg/mL (range 1.53-468.50) in cSLE and 54.98 pg/mL (range 0.69-181.00) in healthy controls (p<0.001). An association was observed between S100 beta protein and NP manifestations (p = 0.03). The S100 beta protein levels was associated with cognitive impairment in cSLE patients (p = 0.006). Conclusions: S100 beta protein levels are increased in cSLE with cognitive impairment. S100 beta may be considered a potential biomarker that underlies central nervous system (CNS) dysfunction, especially cognitive impairment.
Subject: S100 Beta
Neuropsychiatric Manifestations
Cognitive Impairment
Childhood-onset Systemic Lupus Erythematosus
Editor: Sage Publications LTD
London
Rights: fechado
Identifier DOI: 10.1177/0961203317691374
Address: http://journals.sagepub.com/doi/abs/10.1177/0961203317691374
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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