Please use this identifier to cite or link to this item:
Type: Artigo
Title: Evaluation Of Low Fluoride Toothpaste Using Primary Enamel And A Validated Ph-cycling Model
Author: de Amoedo Campos Velo
Marilia Mattar; Machado Tabchoury
Cinthia Pereira; Romao
Dayse Andrade; Cury
Jaime Aparecido
Abstract: To develop and validate pH-cycling model for primary enamel, which was then used to evaluate the anti-caries potential of fluoride toothpastes. DesignHuman primary enamel slabs were subjected to pH-cycling model for 10days and maintained for 6h in demineralizing solution and 18h in remineralizing solution daily. Twice/day, the slabs were treated. To validate it, the treatments were water or solutions containing 62.5, 125, 250, and 375gF/mL. Commercial toothpastes containing no fluoride, 500, 1100, and 1450gF/g were evaluated. Demineralization was assessed by percentage of surface hardness loss (%SHL) and cross-sectional hardness (S). Fluoride dose-response effect was analysed by quadratic regression and the effects of toothpastes by Tukey's test. ResultsDose-response effect was found between fluoride concentration and %SHL (R-2=0.7047; P<0.01) or S (R-2=0.4465; P<0.01). %SHL and S (meanSD) for the group treated with 500gF/g toothpaste was 36.6 +/- 8.0 and 6298.5 +/- 1221.3, respectively, which were significantly higher than those treated with 1100 (25.2 +/- 8.7; 4565.7 +/- 1122) and 1450gF/g (24.2 +/- 5.2; 2339.1 +/- 879.7) toothpastes. ConclusionThe developed pH-cycling model may be used to evaluate and compare the anti-caries potential of toothpaste formulations with low fluoride concentration because it presents dose-response effects on the reduction of primary enamel demineralization.
Editor: Wiley-Blackwell
Rights: fechado
Identifier DOI: 10.1111/ipd.12209
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000385738000005.pdf285.49 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.