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|Title:||The Utility Of International Society On Thrombosis And Haemostasis-bleeding Assessment Tool And Other Bleeding Questionnaires In Assessing The Bleeding Phenotype In Two Platelet Function Defects|
|Abstract:||The main objective of this study is to investigate the utility of International Society on Thrombosis and Haemostasis-Bleeding Assessment Tool (ISTH-BAT) in comparison with the condensed form of Molecular and Clinical Markers for the Diagnosis and Management of type 1 and WHO BATs, in assessing bleeding in two well known and clinically significant platelet function defects. Thirty-eight patients previously diagnosed with Glanzmann's thrombasthenia and 10 with Bernard-Soulier syndrome (BSS) were analyzed. Bleeding scores were significantly higher than that of controls using both electronic bleeding questionnaire (eBQ) and ISTH-BAT with no significant difference between both tools. ISTH-BAT had a sensitivity, specificity, positive predictive value and negative predictive value of 100%, 76.2%, 0.9 and 1. This was closely similar to eBQ. Both ISTH-BAT and eBQ are efficient in BSS and Glanzmann's thrombasthenia. However, given the ISTH recommendation, ISTH-BAT should be adopted. Larger study including other platelet defects will enhance its utility and support the integration of bleeding scores with standardized laboratory testing to allow for a universal diagnostic approach to patients with suspected bleeding disorders. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.|
Platelet Function Defect
|Editor:||Lippincott Williams & Wilkins|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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