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Type: Artigo
Title: Deracemization Of 1-phenylethanol Via Tandem Biocatalytic Oxidation And Reduction
Author: Nasario
Fabio D.; Cazetta
Tarcila; Moran
Paulo J. S.; Rodrigues
J. Augusto R.
Abstract: (R)-1-Arylethanols and other secondary alcohols were prepared at high ee (>90%) by oxidative kinetic resolution using resting cells of the yeast Candida albicans CCT 0776. The deracemization process of 1-phenylethanol la catalyzed by the yeast was elucidated by studying each step separately. It was determined that the reaction occurred via cyclic deracemization, to give (R)-1a in 89% yield and with 98% ee. Finally, deracemization by stereoinversion of rac-1a was studied using a tandem process of C. albicans followed by Lactobacillus brevis CCT 3745. Inverting the sequence of these microorganisms produced an enantiomerically pure antipode. (C) 2016 Published by Elsevier Ltd.
Editor: Pergamon-Elsevier Science LTD
Citation: Tetrahedron: Asymmetry. Pergamon-elsevier Science Ltd , v. 27, p. 404 - 409, 2016.
Rights: fechado
Identifier DOI: 10.1016/j.tetasy.2016.03.008
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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