Please use this identifier to cite or link to this item:
|Title:||Deracemization Of 1-phenylethanol Via Tandem Biocatalytic Oxidation And Reduction|
Fabio D.; Cazetta
Paulo J. S.; Rodrigues
J. Augusto R.
|Abstract:||(R)-1-Arylethanols and other secondary alcohols were prepared at high ee (>90%) by oxidative kinetic resolution using resting cells of the yeast Candida albicans CCT 0776. The deracemization process of 1-phenylethanol la catalyzed by the yeast was elucidated by studying each step separately. It was determined that the reaction occurred via cyclic deracemization, to give (R)-1a in 89% yield and with 98% ee. Finally, deracemization by stereoinversion of rac-1a was studied using a tandem process of C. albicans followed by Lactobacillus brevis CCT 3745. Inverting the sequence of these microorganisms produced an enantiomerically pure antipode. (C) 2016 Published by Elsevier Ltd.|
|Editor:||Pergamon-Elsevier Science LTD|
|Citation:||Tetrahedron: Asymmetry. Pergamon-elsevier Science Ltd , v. 27, p. 404 - 409, 2016.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.