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Type: Artigo
Title: Sleep Disorders In Machado-joseph Disease
Author: Pedroso
Jose Luiz; Braga-Neto
Pedro; Martinez
Alberto R. M.; Martins Junior
Carlos R.; Rezende Filho
Flavio M.; Sobreira-Neto
Manoel A.; Prado
Lucila B. F.; do Prado
Gilmar F.; Franca Junior
Marcondes C.; Barsottini
Orlando G. P.
Abstract: Purpose of reviewThis article provides a description on clinical features and pathophysiology of the main sleep disorders observed in Machado-Joseph disease (MJD).Recent findingsPathological studies have clearly demonstrated that degenerative process in MJD is widespread in the nervous system, and not restricted to the cerebellum. Nonmotor manifestations are frequent and may include pain, cramps, dysautonomia, cognitive deficits, psychiatric manifestations, olfactory deficits, fatigue, nutritional issues, and sleep disorders.SummarySleep disorders are frequent in MJD, and include restless legs syndrome, rapid eye movement sleep behavior disorder, excessive daytime sleepiness, insomnia, sleep apnea, periodic limb movements during sleep, parasomnia, and others. Pathophysiological mechanisms related to sleep disorders in Machado-Joseph are complex and poorly understood. Considering that sleep complaints are a treatable condition, recognizing sleep disorders in MJD is relevant.
Subject: Machado-joseph Disease
Nonmotor Symptoms
Sleep Disorders
Spinocerebellar Ataxia Type 3
Editor: Lippincott Williams & Wilkins
Rights: fechado
Identifier DOI: 10.1097/YCO.0000000000000287
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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