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Type: Artigo
Title: Plag1 Expression Is Maintained In Recurrent Pleomorphic Adenoma
Author: de Brito
Beatriz Samara; Gaspar
Natalia Giovanelli; Abu Egal
Erika Said; Sanchez-Romero
Celeste; Martins
Antonio Santos; Tincani
Alfio Jose; Gondak
Rogerio de Oliveira; de Almeida
Oslei Paes; Kowalski
Luiz Paulo; Altemani
Albina; Mariano
Fernanda Viviane
Abstract: The proto-oncogene (pleomorphic adenoma gene 1 (PLAG1)) is immunohistochemically overexpressed in pleomorphic adenoma (PA). Its expression in recurrent pleomorphic adenoma (RPA), however, has not been investigated. Since complex mechanisms are involved in tumor recurrence, the aim of this study was to investigate whether PLAG1 overexpression occurs in RPA. We studied PLAG1 protein expression in 40 PAs and 36 RPAs by immunohistochemistry. Cases with immunopositive cells were classified into two categories, between 10 and 50 % and > 50 %. In both groups, PLAG1 expression was observed in both epithelial and myoepithelial cells. Of PAs, 37 cases (93 %) were positive, while this was the case in 34 RPA cases (94 %). Our findings suggest that in addition to morphological similarity, PA and RPA express PLAG1, which might play a role in tumor recurrence. Furthermore, as for PA, expression of PLAG1 can be considered a valuable diagnostic marker for RPA.
Subject: Pleomorphic Adenoma
Recurrent Pleomorphic Adenoma
Editor: Springer
New York
Rights: fechado
Identifier DOI: 10.1007/s00428-016-1980-3
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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