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Type: Artigo
Title: Antimicrobial Activity Against Gram-positive And Gram-negative Bacteria During Gatifloxacin Degradation By Hydroxyl Radicals
Author: Caianelo
Marlon; Rodrigues-Silva
Caio; Maniero
Milena Guedes; Guimaraes
Jose Roberto
Abstract: Gatifloxacin, an antimicrobial drug belonging to the fluoroquinolone family, is active against Gram-positive and Gram-negative bacteria and is extensively used for the control of infections in humans. The presence of the drug in environmental matrices has already been reported. This study investigated the degradation of gatifloxacin in water by hydroxyl radicals generated by the UV254 nm/H2O2 process (CH2O2initial = 0.4-2.4 mmol L-1) and evaluated the capacity of the radicals to reduce the antimicrobial activity against Gram-positive and Gram-negative bacteria. Acute toxicity assays were performed with Vibrio fischeri, and the degradation products were proposed. The hydroxyl radicals formed in the processes were able to degrade the fluoroquinolone and remove the antimicrobial activity from the aqueous solution. Approximately 97 % gatifloxacin degradation was observed after applying 2.4 mmol L-1 of initial H2O2 concentration and 20 min of UVC254nm irradiation (130 J s(-1)). The acute toxicity assays showed that the toxicity of the treated solution for V. fischeri increased as the gatifloxacin concentration in the solution decreased.
Subject: Acute Toxicity
Advanced Oxidation Process
Antimicrobial Activity
Drinking Water
Fluoroquinolone Degradation Products
Editor: Springer Heidelberg
Citation: Environmental Science And Pollution Research. Springer Heidelberg, v. 24, p. 6288 - 6298, 2017.
Rights: fechado
Identifier DOI: 10.1007/s11356-016-6972-y
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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