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Type: Artigo
Title: Abnormal Expression Of Inflammatory Genes In Placentas Of Women With Sickle Cell Anemia And Sickle Hemoglobin C Disease
Author: Baptista
Leticia C.; Costa
Maria Laura; Ferreira
Regiane; Albuquerque
Dulcineia M.; Lanaro
Carolina; Fertrin
Kleber Y.; Surita
Fernanda G.; Parpinelli
Mary A.; Costa
Fernando F.; de Melo
Monica Barbosa
Abstract: Sickle cell disease (SCD) is a complex disease that is characterized by the polymerization of deoxyhemoglobin S, altered red blood cell membrane biology, endothelial activation, hemolysis, a procoagulant state, acute and chronic inflammation, and vaso-occlusion. Among the physiological changes that occur during pregnancy, oxygen is consumed by fetal growth, and pregnant women with SCD are more frequently exposed to low oxygen levels. This might lead to red blood cells sickling, and, consequently, to vaso-occlusion. The mechanisms by which SCD affects placental physiology are largely unknown, and chronic inflammation might be involved in this process. This study aimed to evaluate the gene expression profile of inflammatory response mediators in the placentas of pregnant women with sickle cell cell anemia (HbSS) and hemoglobinopathy SC (HbSC). Our results show differences in a number of these genes. For the HbSS group, when compared to the control group, the following genes showed differential expression: IL1RAP (2.76-fold), BCL6 (4.49-fold), CXCL10 (-2.12-fold), CXCR1 (-3.66-fold), and C3 (-2.0-fold). On the other hand, the HbSC group presented differential expressions of the following genes, when compared to the control group: IL1RAP (4.33-fold), CXCL1 (3.05-fold), BCL6 (4.13-fold), CXCL10 (-3.32-fold), C3 (-2.0-fold), and TLR3 (2.38-fold). Taken together, these data strongly suggest a differential expression of several inflammatory genes in both SCD (HbSS and HbSC), indicating that the placenta might become an environment with hypoxia, and increased inflammation, which could lead to improper placental development.
Subject: Sickle Cell Disease
Gene Expression
Editor: Springer
New York
Citation: Annals Of Hematology. Springer, v. 95, p. 1859 - 1867, 2016.
Rights: fechado
Identifier DOI: 10.1007/s00277-016-2780-1
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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