Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326746
Type: Artigo
Title: Antiproliferative Effect Of Synthetic Cyclic Imides (methylphtalimides, Carboxylic Acid Phtalimides And Itaconimides) Against Human Cancer Cell Lines
Author: Stiz
Dorimar; Campos
Adriana; Tasca Gois Ruiz
Ana Lucia; de Carvalho
Joao Ernesto; Correa
Rogerio; Cechinel-Filho
Valdir
Abstract: This work describes the antiproliferative potential of 14 cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against several human cancer cell lines. The antiproliferative effect was evaluated using the sulforhodamine B assay. Although some compounds from methylphtalimide and carboxylic acid phtalimide classes exhibited a selective antiproliferative activity, the itaconimides (11-14) exhibited the best results, especially compound 14, which presented a TGI (concentration that produces total growth inhibition) value of 0.0043 mu M against glioma (U251), being inactive against the non-tumor cell line (HaCat). Absorption, distribution, metabolism and excretion in silico evaluations suggest that these compounds are promising candidates.
Subject: Adme
Antiproliferative Effect
Cyclic Imides
Itaconimides
Editor: Walter De Gruyter GMBH
Berlin
Rights: fechado
Identifier DOI: 10.1515/znc-2016-0067
Address: https://www.degruyter.com/view/j/znc.2016.71.issue-11-12/znc-2016-0067/znc-2016-0067.xml
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.