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Type: Artigo
Title: Antiproliferative Effect Of Synthetic Cyclic Imides (methylphtalimides, Carboxylic Acid Phtalimides And Itaconimides) Against Human Cancer Cell Lines
Author: Stiz
Dorimar; Campos
Adriana; Tasca Gois Ruiz
Ana Lucia; de Carvalho
Joao Ernesto; Correa
Rogerio; Cechinel-Filho
Abstract: This work describes the antiproliferative potential of 14 cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against several human cancer cell lines. The antiproliferative effect was evaluated using the sulforhodamine B assay. Although some compounds from methylphtalimide and carboxylic acid phtalimide classes exhibited a selective antiproliferative activity, the itaconimides (11-14) exhibited the best results, especially compound 14, which presented a TGI (concentration that produces total growth inhibition) value of 0.0043 mu M against glioma (U251), being inactive against the non-tumor cell line (HaCat). Absorption, distribution, metabolism and excretion in silico evaluations suggest that these compounds are promising candidates.
Subject: Adme
Antiproliferative Effect
Cyclic Imides
Editor: Walter De Gruyter GMBH
Citation: Zeitschrift Für Naturforschung C - A Journal Of Biosciences. Walter De Gruyter Gmbh, v. 71, p. 423 - 427, 2016.
Rights: fechado
Identifier DOI: 10.1515/znc-2016-0067
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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