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|Title:||Antiproliferative Effect Of Synthetic Cyclic Imides (methylphtalimides, Carboxylic Acid Phtalimides And Itaconimides) Against Human Cancer Cell Lines|
Adriana; Tasca Gois Ruiz
Ana Lucia; de Carvalho
Joao Ernesto; Correa
|Abstract:||This work describes the antiproliferative potential of 14 cyclic imides (methylphtalimides, carboxylic acid phtalimides and itaconimides) against several human cancer cell lines. The antiproliferative effect was evaluated using the sulforhodamine B assay. Although some compounds from methylphtalimide and carboxylic acid phtalimide classes exhibited a selective antiproliferative activity, the itaconimides (11-14) exhibited the best results, especially compound 14, which presented a TGI (concentration that produces total growth inhibition) value of 0.0043 mu M against glioma (U251), being inactive against the non-tumor cell line (HaCat). Absorption, distribution, metabolism and excretion in silico evaluations suggest that these compounds are promising candidates.|
|Editor:||Walter De Gruyter GMBH|
|Citation:||Zeitschrift FÃ¼r Naturforschung C - A Journal Of Biosciences. Walter De Gruyter Gmbh, v. 71, p. 423 - 427, 2016.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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