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Type: Artigo
Title: Current Concepts In The Treatment Of Hereditary Ataxias
Author: Braga-Neto
Pedro; Pedroso
Jose Luiz; Kuo
Sheng-Han; Franca Junior
Marcondes C.; Ghizoni Teive
Helio Afonso; Povoas Barsottini
Orlando Graziani
Abstract: Hereditary ataxias (HA) represents an extensive group of clinically and genetically heterogeneous neurodegenerative diseases, characterized by progressive ataxia combined with extra-cerebellar and multi-systemic involvements, including peripheral neuropathy, pyramidal signs, movement disorders, seizures, and cognitive dysfunction. There is no effective treatment for HA, and management remains supportive and symptomatic. In this review, we will focus on the symptomatic treatment of the main autosomal recessive ataxias, autosomal dominant ataxias, X-linked cerebellar ataxias and mitochondrial ataxias. We describe management for different clinical symptoms, mechanism-based approaches, rehabilitation therapy, disease modifying therapy, future clinical trials and perspectives, genetic counseling and preimplantation genetic diagnosis.
Subject: Hereditary Ataxias
Rehabilitation Therapy
Disease Modifying Therapy
Editor: Assoc Arquivos Neuro- Psiquiatria
São Paulo
Rights: aberto
Identifier DOI: 10.1590/0004-282X20160038
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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