Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326688
Type: Artigo
Title: Association Between Levobupivacaine And Pancuronium. Interference In Neuromuscular Transmission And Blockade In Rats
Author: Carvalho
Vanessa Henriques; de Assuncao Braga
Angelica de Fatima; da Silva Braga
Franklin Sarmento; Braga Poterio
Gloria Maria; Caparica Santos
Filipe Nadir; Feres Junqueira
Fernando Eduardo
Abstract: To evaluate the effects of levobupivacaine on neuromuscular transmission and neuromuscular blockade produced by pancuronium in vitro. METHODS: Thirty rats were distributed into groups (n = 5) according to the drug used alone or in combination: Group I - levobupivacaine (5 mu g.mL-(1)); Group II - pancuronium (2 mu g.mL(-1)); Group III - pancuronium (2 mu g.mL(-1)) + levobupivacaine (5 mu g.mL(-1)). The following parameters were evaluated: 1) amplitude of diaphragmatic response to indirect stimulation, before and 60 minutes after the addition of levobupivacaine and pancuronium alone, and after the addition of levobupivacaine combined with pancuronium; 2) membrane potentials (MP) and miniature endplate potentials (MEPP). RESULTS: Levobupivacaine alone did not alter the amplitude of muscle response and MP. In preparations previoulsy exposed to levobupivacaine, the block with pancuronium was significantly denser (90.2 +/- 15.2%), showing a significant difference (p=0.031) in comparison to the block produced by pancuronium alone (48.9% +/- 9.8%). There was a decrease in the frequency and amplitude of MEPPs. CONCLUSION: Levobupivacaine potentiated the neuromuscular blockade produced by pancuronium, confirming a presynaptic action by a decrease in miniature endplate potentials.
Subject: Pancuronium
Neuromuscular Nondepolarizing Agents
Rats
Editor: Acta Cirurgica Brasileira
São Paulo
Rights: aberto
Identifier DOI: 10.1590/S0102-865020160070000009
Address: http://www.scielo.br/scielo.php?pid=S0102-86502016000700486&script=sci_arttext
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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