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Type: Artigo
Title: A Strategy For The Rapid Identification Of Fungal Metabolites And The Discovery Of The Antiviral Activity Of Pyrenocine A And Harzianopyridone
Author: Ioca
Laura P.; Romminger
Stelamar; Santos
Mario F. C.; Bandeira
Karin F.; Rodrigues
Fabiana T.; Kossuga
Miriam H.; Nicacio
Karen J.; Ferreira
Everton L. F.; Morais-Urano
Raquel P.; Passos
Messias S.; Kohn
Luciana K.; Arns
Clarice W.; Sette
Lara D.; Berlinck
Roberto G. S.
Abstract: The isolation and identification of bioactive metabolites from complex extracts obtained from microbial growth media is a time consuming, costly, and labor-intensive task. A strategy to rapidly identify secondary metabolites isolated from extracts obtained from the culture media of marine-derived and endophytic fungal strains is described. Identification was achieved by HPLC-UV-MS and H-1 NMR analyses in combination with data obtained from the Dictionary of Natural Products. Among the compounds identified, (-)-naphthoquinoneimine, citreorosein, emodin, pyrenocine A and harzianopyridone displayed moderate to potent antiviral activity. (-)-Naphthoquinoneimine was isolated as the enantiomer of its previously reported dextrorotatory congener, while 6,7-dihydroxy-2,2- dimethyl-4-chromanone is herein reported for the first time as a natural product.
Subject: Fungal Metabolites
Rapid Identification
Editor: Soc Brasileira Quimica
São Paulo
Citation: Quimica Nova. Soc Brasileira Quimica, v. 39, p. 720 - 731, 2016.
Rights: aberto
Identifier DOI: 10.5935/0100-4042.20160092
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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