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Type: Artigo
Title: Tolfenamic Acid Degradation By Direct Photolysis And The Uv-abc/h2o2 Process: Factorial Design, Kinetics, Identification Of Intermediates, And Toxicity Evaluation
Author: da Silva
Lucas de Melo; Cavalcante
Rodrigo Pereira; Cunha
Rebeca Fabbro; Gozzi
Fabio; Dantas
Renato Falcao; de Oliveira
Silvio Cesar; Machulek Junior
Abstract: This study employed direct UV-ABC photolysis and the UV-ABC/H2O2 process to investigate the degradation of tolfenamic add (TA), a common anti-inflammatory drug used in both human and veterinary medicine. A 23 factorial design with added center point was used to evaluate the effect of three independent variables namely, H2O2 concentration ([H2O2]), TA concentration ([TA]), and experiment time (time) on TA degradation and H2O2 photolysis during UV-ABC/H2O2 treatment using a high-pressure mercury vapor lamp (photon flux of 2.6307 x 10(4) J s(-1)) as the UV irradiation source. The responses yielded similar values, revealing a linear behavior, with correlation coefficients R = 0.9968 and R-adj = 0.9921 for TA degradation and R = 0.9828 and Radj = 0.9570 for H2O2 photolysis. The most efficient combination of variables was [H2O2] = 255 mg L-1 and [TA] = 25 mg L-1, resulting in 100% TA degradation and 98.87%H2O2 photolysis by 90 min of treatment. Additionally, the second order kinetic constant of the reaction between TA and HO center dot was determined using a competitive kinetic model, employing 2,4-dichlorophenoxyacetic acid (2,4D) as the reference compound. The kinetic constant was 1.9 x 1010 1 s-1 in alkaline medium. TA degradation by direct photolysis generated quinone imines as by products, responsible for the formation of a dark red "internal filter" that increased the value of acute toxicity to Artemia saline. The UV-ABC/H2O2 process did not promote formation of quinone imines by 90 min of treatment and therefore did not increase acute toxicity values. Several by-products generated during TA degradation were identified and possible degradation pathways for the UV-ABC and UV-ABC/H2O2 processes were proposed. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Uv-abc/h2o2 Process
Direct Photolysis
Tolfenamic Add
Second-order Kinetic Constant
Acute Toxicity
Editor: Elsevier Science BV
Rights: fechado
Identifier DOI: 10.1016/j.scitotenv.2016.08.139
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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