Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326482
Type: Artigo
Title: Loss Of Expression Of Plag1 In Malignant Transformation From Pleomorphic Adenoma To Carcinoma Ex Pleomorphic Adenoma
Author: de Brito
Beatriz Samara; Giovanelli
Natalia; Egg
Erika Said; Sanchez-Romero
Celeste; do Nascimento
Juliana de Souza; Martins
Antonio Santos; Tincani
Alfio Jose; Del Negro
Andre; Gondak
Rogerio de Oliveira; de Almeida
Oslei Paes; Kowalski
Luiz Paulo; Altemani
Albina; Mariano
Fernanda Viviane
Abstract: PLAG1 (pleomorphic adenoma gene 1) is frequently activated in pleomorphic adenoma (PA). Carcinoma ex pleomorphic adenoma (CXPA) arises in PA, and PLAG1 expression is believed to be maintained from PA to CXPA, as it can contribute to the carcinogenesis process. To evaluate if PLAG1 is a good marker of malignant transformation from PA to CXPA as well as to evaluate if PLAG1 expression is associated with progression and histopathologic subtype of CXPA. Forty PAs, 21 residual PAs (without malignant transformation), and 40 CXPAs were analyzed by immunohistochemistry with PLAG1 antibody. The proportion of positive neoplastic cells was assessed according to a 2-tiered scale: >10% to 50%, and >50% positive cells. The CXPA group was classified according to histopathologic subtype and invasiveness degree. Thirty-seven PAs (92.5%), 15 residual PAs (71%), and 14 CXPAs (35%) were positive for PLAG1. In relation to the CXPA group, among the intracapsular cases, myoepithelial carcinoma and epithelial-myoepithelial carcinoma showed the highest level of PLAG1 expression. PLAG1 expression is lost when PA undergoes malignant transformation, possibly due to other pathway activation and different clone cells. In addition, PLAG1 expression seems to be present mainly in low-grade carcinomas and in cases with early phase of invasion, due to its regulation of oncogene-induced cell senescence. In CXPA, PLAG1 expression was most associated with myoepithelial differentiation. This way, loss of PLAG1 expression can be considered a hallmark of CXPA carcinogenesis, mainly when there is only epithelial differentiation. (C) 2016 Elsevier Inc. All rights reserved.
Subject: Pleomorphic Adenoma
Carcinoma Ex Pleomorphic Adenoma
Plag1
Immunohistochemistry
Malignant Transformation
Carcinogenesis
Editor: W B Saunders Co-Elsevier Inc
Philadelphia
Rights: fechado
Identifier DOI: 10.1016/j.humpath.2016.07.011
Address: http://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0046817716301630
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000386644600021.pdf2.04 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.