Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326452
Type: Artigo
Title: Relationship Between The Iga Antibody Response Against Streptococcus Mutans Gbpb And Severity Of Dental Caries In Childhood
Author: Colombo
Natalia Helena; Pereira
Jesse Augusto; Rodrigues da Silva
Marjully Eduardo; Fonseca Ribas
Lais Fernanda; Parisotto
Thais Manzano; Mattos-Graner
Renata de Oliveira; Smith
Daniel J.; Duque
Cristiane
Abstract: Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design: 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results: S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions: This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC. (C) 2016 Elsevier Ltd. All rights reserved.
Subject: Early Childhood Caries
Imunoglobulin A
S. Mutans
Glucan Binding Proteins
Editor: Pergamon-Elsevier Science LTD
Oxford
Rights: fechado
Identifier DOI: 10.1016/j.archoralbio.2016.03.006
Address: http://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0003996916300632
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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