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Type: Artigo
Title: Botulinum Toxin Type A Reduces Inflammatory Hypernociception Induced By Arthritis In The Temporomadibular Joint Of Rats
Author: Manuel Munoz Lora
Victor Ricardo; Clemente-Napimoga
Juliana Trindade; Abdalla
Henrique Ballassini; Macedo
Cristina Gomes; Canales
Giancarlo de la Torre; Rizzatti Barbosa
Celia Marisa
Abstract: This study aimed to investigate the antinociceptive effects of Botulinum toxin type A (BoNT-A) on persistent inflammatory hypernociception induced by arthritis in the temporomandibular joint (TMJ) of rats. Material and methods: Wistar rats were induced to persistent inflammatory hypernociception in the left TMJ. Then, animals were treated with intra-TMJ injections of BoNT-A, using doses of 3.5, 7 and 14 U/kg. Saline was used as control group. Behavioral tests were applied to evaluated the effect of BoNT-A in the inflammatory hypernociception. After that, animals were euthanized and samples from peri-articular tissues and trigeminal ganglia were obtained for further analyses. Results: BoNT-A reduced the persistent inflammatory hypernociception induced by arthritis in the TMJ of rats. BoNT-A significantly reduced the peripheral release of the neurotransmitters Substance P and Calcitonin gene related peptide; and the pro-inflammatory cytokine IL-10. Otherwise, BoNT-A had no effect in the peripheral release of glutamate and the cytokine TNF-alpha. Conclusion: These results demonstrate that intra-articular injection of BoNT-A reduces the albumin induced arthritis persistent hypernociception in TMJ of rats by peripheral inhibition of neuropeptides release. 2017 Elsevier Ltd. All rights reserved.
Subject: Botulinum Toxins Type A
Editor: Pergamon-Elsevier Science LTD
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2017.02.010
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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