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Type: Artigo
Title: Antibodies For Rickettsia Spp. In Patients With Negative Serology For Dengue Virus, Leptospirosis, And Meningococcal Disease In Municipalities Of Sao Paulo State, Brazil
Author: Cabral Prata
Juliana Anacleto; de Souza
Celso Eduardo; Angerami
Rodrigo Nogueira; Cotrim de Moraes Barbosa
Taise Marongio; Pereira dos Santos
Fabiana Cristina; Colombo
Silvia; Fontes Del Guercio
Vania Martins; Donalisio
Maria Rita
Abstract: Brazilian spotted fever is an infectious disease with a high mortality rate if not treated early. Differential diagnosis is difficult, as the first clinical signs are non-specific and can be confused with other diseases. The aim of the study was to investigate evidence of infection with Rickettsia rickettsii and Rickettsia parkeri in negative sera samples, collected in 2014, from patients with suspected leptospirosis, dengue fever, and meningococcal disease in Atibaia and Braganca Paulista municipalities of the State of Sao Paulo. Methods: The samples stored at the Institute Adolfo Lutz in Campinas were tested using an indirect immunofluorescence assay (IFA) with IgG and IgM against R. rickettsii and R. parkeri. Real-time polymerase chain reaction (PCR) testing was performed for the sera samples of patients who died (n = 3), those with initial suspicion of meningococcal disease (n = 6), and those with positive IFA results. Results: Of 258 samples from Braganca Paulista, 4 (1.6%) were positive, with IgG titers of 1: 64 and 1: 128 against R. rickettsii and R. parkeri, respectively. Of 155 samples from Atibaia, 2 (1.3%) were positive, with IgG titers of 1: 64 and 1: 128 against R. rickettsii and R. parkeri, respectively. No sample showed positive PCR results. Conclusions: This serological investigation suggests there is evidence of exposure to Rickettsia spp. in residents of areas that have environmental conditions favorable to the spread of bacteria, in which Brazilian spotted fever incidence was not previously confirmed.
Subject: Brazilian Spotted Fever
Rickettsia Rickettsii
Rickettsia Parkeri
Indirect Immunofluorescence Test
Differential Diagnosis
Editor: Soc Brasileira Medicina Tropical
Rights: aberto
Identifier DOI: 10.1590/0037-8682-0023-2016
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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