Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326394
Type: Artigo
Title: Nad(+) Repletion Improves Mitochondrial And Stem Cell Function And Enhances Life Span In Mice
Author: Zhang
Hongbo; Ryu
Dongryeol; Wu
Yibo; Gariani
Karim; Wang
Xu; Luan
Peiling; D'Amico
Davide; Ropelle
Eduardo R.; Lutolf
Matthias P.; Aebersold
Ruedi; Schoonjans
Kristina; Menzies
Keir J.; Auwerx
Johan
Abstract: Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD(+)) and its effect on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence. Treatment with the NAD(+) precursor nicotinamide riboside (NR) induced the mitochondrial unfolded protein response and synthesis of prohibitin proteins, and this rejuvenated MuSCs in aged mice. NR also prevented MuSC senescence in the mdx (C57BL/10ScSn-Dmd(mdx)/J) mouse model of muscular dystrophy. We furthermore demonstrate that NR delays senescence of neural SCs and melanocyte SCs and increases mouse life span. Strategies that conserve cellular NAD(+) may reprogram dysfunctional SCs and improve life span in mammals.
Editor: Amer Assoc Advancement Science
Washington
Rights: fechado
Identifier DOI: 10.1126/science.aaf2693
Address: http://science-sciencemag-org.ez88.periodicos.capes.gov.br/content/352/6292/1436
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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