Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326352
Type: Artigo
Title: Antiproliferative Constituents Of Geopropolis From The Bee Melipona Scutellaris
Author: da Cunha
Marcos Guilherme; Rosalen
Pedro Luiz; Franchin
Marcelo; de Alencar
Severino Matias; Ikegaki
Masaharu; Ransom
Tanya; Beutler
John Albert
Abstract: Fractionation of geopropolis from Melipona scutellaris, guided by antiproliferative activity against two colon cancer cell lines (COLO205 and KM12), led to the isolation of two new cinnamic acid esters, mammea-type coumarins 5,7-dihydroxy-6(3-methyl-2-butenyl)-8-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-propyl-coumarin (1) and 5,7-dihydroxy-6-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-phenylcoumarin (2), along with five known coumarins, mammeigin (3), hydroxymammeigin (4), mammeisin (5), cinnamoyloxy-mammeisin (6), and mammein (7), and the prenylated benzophenone ent-nemorosone (8). Among the isolated compounds, 5 and 7 showed the highest cell growth inhibition against COLO205 (GI(50) 9.7 and 10.7 mu M, respectively) and KM12 (GI(50) 12.0 and 10.9 mu M, respectively). The presence of these compounds suggests that plants of Clusiaceae family, especially the genera Kielmeyera and Clusia, are likely to be major sources of geopropolis produced by M. scutellaris.
Subject: Clusiaceae
Geopropolis
Melipona Scutellaris
Cytotoxity
Coumarins
Editor: Georg Thieme Verlag KG
Stuttgart
Rights: aberto
Identifier DOI: 10.1055/s-0035-1558142
Address: https://www-thieme-connect-com.ez88.periodicos.capes.gov.br/products/ejournals/html/10.1055/s-0035-1558142
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000369948100002.pdf123.59 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.