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Type: Artigo
Title: Antiproliferative Constituents Of Geopropolis From The Bee Melipona Scutellaris
Author: da Cunha
Marcos Guilherme; Rosalen
Pedro Luiz; Franchin
Marcelo; de Alencar
Severino Matias; Ikegaki
Masaharu; Ransom
Tanya; Beutler
John Albert
Abstract: Fractionation of geopropolis from Melipona scutellaris, guided by antiproliferative activity against two colon cancer cell lines (COLO205 and KM12), led to the isolation of two new cinnamic acid esters, mammea-type coumarins 5,7-dihydroxy-6(3-methyl-2-butenyl)-8-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-propyl-coumarin (1) and 5,7-dihydroxy-6-(4-cinnamoyl-3-methyl-1-oxobutyl)-4-phenylcoumarin (2), along with five known coumarins, mammeigin (3), hydroxymammeigin (4), mammeisin (5), cinnamoyloxy-mammeisin (6), and mammein (7), and the prenylated benzophenone ent-nemorosone (8). Among the isolated compounds, 5 and 7 showed the highest cell growth inhibition against COLO205 (GI(50) 9.7 and 10.7 mu M, respectively) and KM12 (GI(50) 12.0 and 10.9 mu M, respectively). The presence of these compounds suggests that plants of Clusiaceae family, especially the genera Kielmeyera and Clusia, are likely to be major sources of geopropolis produced by M. scutellaris.
Subject: Clusiaceae
Melipona Scutellaris
Editor: Georg Thieme Verlag KG
Rights: aberto
Identifier DOI: 10.1055/s-0035-1558142
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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