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Type: Artigo
Title: Gastroprotective Effects Of Hydroethanolic Root Extract Of Arrabidaea Brachypoda: Evidences Of Cytoprotection And Isolation Of Unusual Glycosylated Polyphenols
Author: da Rocha
Claudia Quintino; de-Faria
Felipe Meira; Marcourt
Laurence; Ebrahimi
Samad Nejad; Kitano
Bruna Tiemi; Ghilardi
Amanda Franceschini; Ferreira
Anderson Luiz; de Almeida
Ana Cristina Alves; Dunder
Ricardo Jose; Monteiro Souza-Brito
Alba Regina; Hamburger
Matthias; Vilegas
Wagner; Queiroz
Emerson Ferreira; Wolfender
Abstract: The hydroethanolic root extract of Arrabidaea brachypoda, from Bignoniaceae family, a Brazilian me-dicinal plant, demonstrated significant in vivo gastroprotective effects using different in vivo assays. The activity was evaluated in several models of experimental gastric ulcer in rats (absolute ethanol, gluta-thione depletion, nitric oxide depletion, non-steroidal anti-inflammatory drugs, pylorus ligation and acetic acid). Using 300 mg/kg (p.o.) the extract significantly reduced gastric injury in all models. In depth phytochemical investigation of this extract led to the isolation of two previously undescribed phenyl-ethanoid glycosides derivatives and seven unusual glycosylated dimeric flavonoids. The structures were elucidated using UV, NMR and HRMS analysis. Absolute configuration of the dimeric flavonoids was performed by electronic circular dichroism (ECD) spectroscopy. (C) 2016 Elsevier Ltd. All rights reserved.
Subject: Arrabidaea Brachypoda
Gastric Ulcer
Gastroprotective Effect
In Vivo Assays
Glycosylated Dimeric Flavonoids
Editor: Pergamon-Elsevier Science LTD
Citation: Phytochemistry. Pergamon-elsevier Science Ltd , v. 135, p. 93 - 105, 2017.
Rights: fechado
Identifier DOI: 10.1016/j.phytochem.2016.12.002
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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