Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326339
Type: Artigo
Title: Antiprotozoal And Antioxidant Alkaloids From Alternanthera Littoralis
Author: Koolen
Hector H. F.; Pral
Elizabeth M. F.; Alfieri
Silvia C.; Marinho
Jane V. N.; Serain
Alessandra F.; Hernandez-Tasco
Alvaro J.; Andreazza
Nathalia L.; Salvador
Marcos J.
Abstract: Five alkaloids, in addition to hydroxytyrosol and uridine, were isolated from aerial parts of Alternanthera littoralis P. Beauv. Among the isolated compounds, alternamide A was an unusual tricyclic alkaloid with a bridged benzoazepine core. All isolated alkaloids have a catechol moiety, indicating a possible common biosynthetic route. Their structures were established by 1D and 2D NMR spectroscopy in combination with extensive tandem MS experiments by collisional induced dissociation (CID). The antiprotozoal activity of the isolated compounds was assayed against trypomastigote forms of Trypanosoma cruzi and amastigotes of Leishmania amazonensis. Alternamine A was the most active compound, reducing markedly the viability of both parasites. Antioxidant capacities evaluated by ORAC(FL) assay showed that the isolated alkaloids (mainly alternamide B) contributed to the high activity recorded for the ethanolic crude extract; possibly, the catechol moiety present in all structures plays a central role in this result. (C) 2016 Elsevier Ltd. All rights reserved.
Subject: Alternanthera Littoralis
Amaranthaceae
Alkaloids
Antiprotozoal Activities
Antioxidant Activity
Catechol
Editor: Pergamon-Elsevier Science LTD
Oxford
Rights: fechado
Identifier DOI: 10.1016/j.phytochem.2016.11.008
Address: http://www.sciencedirect.com/science/article/pii/S0031942216302588?via%3Dihub
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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