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Type: Artigo
Title: Micrornas-424 And 206 Are Potential Prognostic Markers In Spinal Onset Amyotrophic Lateral Sclerosis
Author: de Andrade
Helen M. T.; de Albuquerque
Milena; Avansini
Simoni H.; Rocha
Cristiane de S.; Dogini
Danyella B.; Nucci
Anamarli; Carvalho
Benilton; Lopes-Cendes
Iscia; Franca
Marcondes C.
Abstract: Introduction: Skeletal muscle microRNAs (miRNAs) are potential candidate biomarkers for amyotrophic lateral sclerosis (ALS) that deserve further investigation. Objectives: To identify miRNAs abnormally expressed in the skeletal muscle and plasma of patients with ALS, and to correlate them with parameters of disease progression. Methods: Expression profile of miRNAs in muscle was evaluated using an array platform. Subsequently we assessed the plasmatic expression of candidate miRNAs in a set of 39 patients/39 controls. We employed generalized estimating equations to investigate correlations with clinical data. Results: We identified 11 miRNAs differentially expressed in the muscle of ALS patients; of these, miR424, miR-214 and miR-206 were validated by qPCR in muscle samples. In plasma, we found only miR-424 and miR 206 to be overexpressed. Baseline expression of miR-424 and 206 correlated with clinical deterioration over time. Conclusion: MiR-424 and miR-206 are potential prognostic markers for ALS. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Microrna
Amyotrophic Lateral Sclerosis
Skeletal Muscle
Motor Neuron
Editor: Elsevier Science BV
Rights: fechado
Identifier DOI: 10.1016/j.jns.2016.06.046
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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