Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326150
Type: Artigo
Title: Decrease Of Pericytes Is Associated With Liver Disease Caused By Ligature-induced Periodontitis In Rats
Author: Pereira Vasconcelos
Daniel Fernando; Pereira da Silva
Felipe Rodolfo; Pinto
Moara e Silva Conceicao; Bastos Santana
Lucas de Araujo; Souza
Ingrid Grazielle; Miranda de Souza
Luan Kelves; Martins Oliveira
Natassia Cristina; Ventura
Claudio Angelo; Novaes
Pedro Duarte; dos Reis Barbosa
Andre Luiz; Medeiros
Jand-Venes Rolim; Mikolasevic
Ivana; Mani
Arya; de Oliveira
Jefferson Soares
Abstract: Damage caused by periodontitis not only affects periodontal tissues, but also increases the severity of various illnesses such as rheumatoid arthritis, diabetes, and liver diseases. The aim of this study is to investigate the association between induced periodontitis and damage caused through its systemic effects on the liver. Methods: Twenty rats were divided into two groups: control and periodontitis. The following parameters were evaluated: gingival bleeding index (GBI), probing depth (PD), myeloperoxidase (MPO) activity, alveolar bone loss (ABL) for periodontal tissues; histopathologic examination of gingival and liver tissues; immunohistochemistry to cells positive for neural/glial antigen 2 (NG2) expressed in hepatic pericytes, glutathione (GSH), and malondialdehyde (MDA) concentrations in liver; and serum levels of alanine aminotransferase and aspartate aminotransferase. Results: GBI, PD, MPO, ABL, and histopathologic examinations demonstrated the development of periodontitis. There was a significant increase in microvesicular steatosis accompanied by a marked reduction in NG2+ pericytes in the periodontitis group compared with the control group. The periodontitis group had significantly lower GSH and higher MDA concentration in the liver compared with the control group. Conclusions: The present study results link the systemic effects of induced periodontitis with changes in hepatic tissues such as microvesicular steatosis, likely caused by an increase in oxidative stress and lipid peroxidation. The findings from the present study implicate an association between a decrease of pericytes and liver disease caused by ligature-induced periodontitis in rats.
Subject: Fatty Liver
Histology
Non-alcoholic Fatty Liver
Oral Medicine
Oxidative Stress
Risk Factors
Editor: Amer Acad Periodontology
Chicago
Rights: fechado
Identifier DOI: 10.1902/jop.2016.160392
Address: http://www-joponline-org.ez88.periodicos.capes.gov.br/doi/abs/10.1902/jop.2016.160392
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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