Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/326135
Type: Artigo
Title: Synthesis, Spectroscopic Characterizations, Crystal Structures And Dft Studies Of Nalidixic Acid Carbonyl Hydrazones Derivatives
Author: Bergamini
F. R. G.; Ribeiro
M. A.; Lancellotti
M.; Machado
D.; Miranda
P. C. M. L.; Cuin
A.; Formiga
A. L. B.; Corbi
P. P.
Abstract: This article describes the synthesis and characterization of the 1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide (hzd) and six carbonyl hydrazones derivatives of the nalidixic with 1H-pyrrol-2-ylmethylidene (hpyrr), 1H-imidazol-2-ylmethylidene (h2imi), pyridin-2-ylmethylidene (h2py), pyridin-3-ylmethylidene (h3py), pyridin-4-ylmethylidene(h4py) and (2-hydroxyphenyl)methylidene (hsali). The carbonyl hydrazones were characterized by elemental and ESI-QTOF-MS analyses, IR and detailed NMR spectroscopic measurements. The 2D NMR experiments allowed the unambiguous assignment of the hydrogen, carbon and nitrogen atoms, which have not been reported for nalidixic acid carbonyl hydrazone derivatives so far. Crystal structures of hzd and the new carbonyl hydrazones h2imi, hpyrr and h3py were determined by X-ray diffraction studies. Although the synthesis of hzd was reported decades ago, the hzd crystal structure have not been reported yet. Geometric optimizations of all the characterized structures were performed with the aid of DFT studies. Despite the fact that the hydrazones with 2-pyridine carboxylic acid (h2py) and salicyl aldehyde (hsali) were already reported by literature, a detailed spectroscopic study followed by DFT studies are also reported for such compounds in this manuscript. Antimicrobial studies of the compounds are also presented. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Nalidixic Acid
Carbonyl Hydrazones
Crystal Structure
Antimicrobial
Dft
Nmr
Editor: Elsevier Science BV
Amsterdam
Rights: fechado
Identifier DOI: 10.1016/j.molstruc.2016.05.025
Address: http://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0022286016304719
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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