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Type: Artigo
Title: Synthesis, Spectroscopic Characterization, Crystallographic Studies And Antibacterial Assays Of New Copper(ii) Complexes With Sulfathiazole And Nimesulide
Author: Bormio Nunes
Julia Helena; Ferraz de Paiva
Raphael Enoque; Cuin
Alexandre; da Costa Ferreira
Ana Maria; Lustri
Wilton Rogerio; Corbi
Pedro Paulo
Abstract: New ternary copper(II) complexes of sulfathiazole (SFT, C9H8N3O2S2) or nimesulide (NMS, C13H11N2O5S) and 2,2'-bipyridine (bipy) were synthesized, and characterized by chemical and spectroscopic techniques. Elemental analyses indicated a 2:1:1 sulfonamide/copper/bipy composition for both complexes. Mass spectrometric measurements permitted identifying the molecular ions [Cu(SFT)(2)(bipy)+H](+) and [Cu(NMS)(2)(bipy)+H](+) at m/z 728 and 835, respectively, confirming the proposed compositions. Crystal structure of the [Cu(SFT)(2)(bipy)] complex was solved by powder X-ray diffraction analysis (PXRD), attesting that the Cu(II) ion is hexacoordinated in a distorted octahedral geometry. Each SFr molecule coordinates to the metal ion by the nitrogen atoms of the SO2-N group and of the heterocyclic ring. The coordination sphere is completed by a bipyridine. Electronic paramagnetic resonance (EPR) studies were carried out for the [Cu(NMS)(2)(bipy)] complex, indicating a tetragonal environment around the metal ion. It was suggested that NMS coordinates to Cu(II) by the nitrogen and oxygen atoms of the SO2-N group, which was confirmed by infrared spectroscopic studies. Biological studies showed the antibacterial activity of both Cu-SFT and Cu-NMS complexes, with the minimum inhibitory concentration (MIC) values ranging from 0.10 to 0.84 mmol L-1 against Gram-negative bacteria for [Cu(SFT)(2)(bipy)], and from 1.50 to 3.00 mmol L-1 against Gram-positive and -negative bacteria for [Cu(NMS)(2)(bipy)]. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Metal Complexes
Antibacterial Agents
Editor: Elsevier Science BV
Citation: Journal Of Molecular Structure. Elsevier Science Bv, v. 1112, p. 14 - 20, 2016.
Rights: fechado
Identifier DOI: 10.1016/j.molstruc.2016.02.006
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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