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Type: Artigo
Title: Spectroscopic Characterization And Biological Studies In Vitro Of A New Silver Complex With Furosemide: Prospective Of Application As An Antimicrobial Agent
Author: Lustri
Wilton R.; Lazarini
Silmara C.; Lustri
Bruna Cardinali; Corbi
Pedro P.; Silva
Maria Aline C.; Resende Nogueira
Flavia Aparecida; Aquino
Renata; Amaral
Andre C.; Treu Filho
Oswaldo; Massabni
Antonio Carlos; Barud
Hernane da Silva
Abstract: The present article describes the synthesis and biological studies in vitro of a novel silver complex with furosemide (Ag-FSE). Elemental, thermal and mass spectrometric analysis indicated a 1:1 metal/ligand composition, with the molecular formula AgC12H10CIN2O5S. Infrared and nuclear magnetic resonance studies suggest coordination of the ligand to the silver ion by the oxygen atoms of the carboxylate group. Additional Density Functional Theory (DFT) studies led to the proposition of the structure of the Ag-FSE complex. The antibacterial activities of the complex were primarily evaluated by antibiogram assays using the disc diffusion method and minimum inhibitory concentrations (MIC). Moreover, the mutagenicity of the complex was also evaluated to ensure that it is safe for subsequent application. The Ag-FSE complex has shown a significant in vitro antibacterial activity against Gram-positive Staphylococcus aureus (ATCC 25923), Gram negative Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853), and yeast Candida albicans (ATCC 90028). The absence of a mutagenic activity of Ag-FSE against Salmonella Typhimurium bacterial strains in the Ames assay is an extremely important finding for its future use as a drug in medicine. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Furosemide
Silver Complex
Antibacterial Activity
Mutagenic Activity
Editor: Elsevier Science BV
Rights: fechado
Identifier DOI: 10.1016/j.molstruc.2016.12.056
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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