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Type: Artigo
Title: Alpha B-crystallin Interacts And Attenuates The Tyrosine Phosphatase Activity Of Shp2 In Cardiomyocytes Under Mechanical Stress
Author: Goncalves
Danieli C.; Marin
Talita M.; Pereira
Michelle B. M.; Santos
Aline M.; Leme
Adriana F. Paes; Franchini
Kleber G.
Abstract: The small heat shock protein alpha B-Crystallin (CryAB, HspB5) and SH2 domain-containing tyrosine phosphatase 2 (Shp2) are important molecules in heart response to pathophysiological stress. Here we show that CryAB interacts with and potentially regulates Shp2 catalytic activity in stretched cardiomyocytes. Such an interaction requires CryAB oligomer to attenuate Shp2 activation. Stretched cardiomyocytes show a robust CryAB/Shp2 association accompanied by a reduction in the Shp2 phosphatase activity. Accordingly, CryAB knock-down in cardiomyocytes enhances Shp2 activity induced by mechanical stress. These results revealed a new role for CryAB, as a modulator of Shp2 phosphatase activity during a functionally relevant stimulus in cardiomyocytes.
Subject: Cardiomyocytes
Tyrosine Phosphatase
Editor: Wiley-Blackwell
Rights: fechado
Identifier DOI: 10.1002/1873-3468.12235
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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