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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArticlept_BR
dc.titlePolymorphisms In The Il1a And Il1b Genes Are Not Associated With Susceptibility To Chronic Periodontitis In A Brazilian Populationen
dc.title.alternativePolymorphisms In The Il1a And Il1b Genes Are Not Associated With Susceptibility To Chronic Periodontitis In A Brazilian Populationpt_BR
dc.contributor.authorRui B. Brito Juniorpt_BR
dc.contributor.authorAntonio W. Sallumpt_BR
dc.contributor.authorSergio R. P. Linept_BR
unicamp.authorRui B. Brito Junior - Department of Morphology, Faculty of Odontology of Piracicaba – UNICAMP, Antonio W. Sallum - Department of Morphology, Faculty of Odontology of Piracicaba – UNICAMP, Sergio R. P. Line - Department of Periodontology, Faculty of Odontology of Piracicaba – UNICAMPpt_BR
dc.description.abstractThe aim of this study was to investigate the association between polymorphisms in the IL-1a and IL-1b genes and severity of chronic periodontitis in Brazilians. 113 non-smoking subjects over 25 years (mean age 41.6) were divided according to the severity level of periodontal disease: 44 healthy individuals (control group), 31 subjects with moderate and 38 with severe periodontitis. DNA was obtained from epithelial cells through a mouthwash with 3 % glucose and scraping of oral mucosa. The samples were analyzed for IL-1a (- 889) and IL-1b (+3953) polymorphisms using PCR-RFLP. The significance of the differences in the frequencies of the polymorphisms in the control and groups with periodontitis was assessed by Chisquare test (p<0.05). No significant differences in the allele and genotype frequencies were found among the groups. It was concluded that neither polymorphisms IL-1a (-889) and IL-1b (+3953) nor the composite genotype were associated with the severity of chronic periodontal disease in the study population.en
dc.relation.ispartofBrazilian Journal of Oral Sciencespt_BR
dc.relation.ispartofabbreviationbjospt_BR
dc.date.issued2003pt_BR
dc.identifier.citationBrazilian Journal of Oral Sciences, v. 2, n. 7, p. 348-352pt_BR
dc.description.volume2pt_BR
dc.description.issuenumber7pt_BR
dc.description.lastpage348-352pt_BR
dc.rightsabertopt_BR
dc.sourcePPECpt_BR
dc.identifier.eissn1677-3225pt_BR
dc.identifier.doi10.20396/bjos.v2i7.8641716pt_BR
dc.identifier.urlhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641716pt_BR
dc.date.available2017-09-12T14:31:56Z-
dc.date.accessioned2017-09-12T14:31:56Z-
dc.description.provenanceMade available in DSpace on 2017-09-12T14:31:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2003en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/325293-
dc.identifier.idPPEC8641716pt_BR
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