Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/325293
Type: Article
Title: Polymorphisms In The Il1a And Il1b Genes Are Not Associated With Susceptibility To Chronic Periodontitis In A Brazilian Population
Title Alternative: Polymorphisms In The Il1a And Il1b Genes Are Not Associated With Susceptibility To Chronic Periodontitis In A Brazilian Population
Author: Rui B. Brito Junior
Antonio W. Sallum
Sergio R. P. Line
Abstract: The aim of this study was to investigate the association between polymorphisms in the IL-1a and IL-1b genes and severity of chronic periodontitis in Brazilians. 113 non-smoking subjects over 25 years (mean age 41.6) were divided according to the severity level of periodontal disease: 44 healthy individuals (control group), 31 subjects with moderate and 38 with severe periodontitis. DNA was obtained from epithelial cells through a mouthwash with 3 % glucose and scraping of oral mucosa. The samples were analyzed for IL-1a (- 889) and IL-1b (+3953) polymorphisms using PCR-RFLP. The significance of the differences in the frequencies of the polymorphisms in the control and groups with periodontitis was assessed by Chisquare test (p<0.05). No significant differences in the allele and genotype frequencies were found among the groups. It was concluded that neither polymorphisms IL-1a (-889) and IL-1b (+3953) nor the composite genotype were associated with the severity of chronic periodontal disease in the study population.
Rights: aberto
Identifier DOI: 10.20396/bjos.v2i7.8641716
Address: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641716
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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