Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/325128
Type: Article
Title: Susceptibility Of Susceptibility Of Susceptibility Of Candida Candida Spp Oral Isolates For Azolic Spp Oral Isolates For Azolic Antifungals And Amphotericin B
Title Alternative: Susceptibility Of Susceptibility Of Susceptibility Of Candida Candida Spp Oral Isolates For Azolic Spp Oral Isolates For Azolic Antifungals And Amphotericin B
Author: Vivian Fernandes Furlletti
Vivian Fernandes Furlletti
Rita de Cássia Mardegan
Gustavo Alberto Obando-Pereda
Paula Cristina Aníbal
Marta Cristina Texeira Duarte
José Francisco Höfling
Abstract: Aims: Among the oral infections, candidosis may be considered the most frequent, and C. albicans the most prevalent species. Meanwhile, the non-albicans species may also be related to other infections processes and be able to affect the oral cavity, including periodontal disease. In this sense, understanding the relationship between Candida spp. and host, it is necessary and justified the search of mechanisms modulators of infections and treatments against diseases associated with these yeasts. Methods: Nineteen patients with periodontal disease were involved in this study. The aim was evaluate the susceptibility to azoles antifungals fluconozole, itraconazole, ketoconazole and the polienic anfotericin B against Candida spp isolated from three different sites of the oral cavity from these patients (periodontal disease, being periodontal pocket, oral mucosa and ridge gingival), by the minimum inhibitory concentration method – MIC. Results: Among the samples of C. albicans, 88% showed susceptibility depending on the concentration (SCD) and 3.6 % were resistant to at least one antifungal azole studied. Among the others species, 57% presented SDC and 42.8% showed resistance to at least one of the antifungal azole tested. Regarding to Anfotericin B, 90% of the C. albicans isolates and 3% of the nonalbicans showed resistance. There was no occurrence of resistance to the fluconazole and only 3.6% of C. albicans and 40% of the non-albicans were SDC to this antifungal. Conclusions: Patients with periondontal disease showed relevant levels of colonization by Candida spp, mainly at the oral mucosa and periodontal pocket showing important occurrence of SDC and resistance to the antifungals drugs tested.
Subject: Periodontal Disease
Candida Spp.
Antifungical
Minimal Inhibitory Concentration
Rights: aberto
Identifier DOI: 10.20396/bjos.v7i25.8642889
Address: https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8642889
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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