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Type: Artigo
Title: 90-kda N-domain Angiotensin I-converting Enzyme (ace): Possible Marker For Hypertension In A Renal Transplant Model
Title Alternative: Enzima Conversora De Angiotensina I (eca) N-domínio 90-kda: Possível Marcador Para Hipertensão Em Modelo De Transplante Renal
Author: Leite
Cleber A; Bertoncello
Nádia SC; Watanabe
Ingrid KM; Fernandes
Fernanda B; Andrade
Maria Claudina C; Ronchi
Fernanda A; Arita
Danielle Y; Marcondes
Fernanda K; Cunha
Tatiana S; Casarini
Dulce E
Abstract: Hypertension is nearly universal in kidney transplant and several factors are associated with post transplant hypertension, including immunosuppressive medications and genetic predisposition. Objective: The aims were to evaluate the effects of spontaneously hypertensive rats (SHR) kidney transplantation in Wistar rats and the possible transference of 80/90-kDa N-domain ACE. Methods: To do so, the data from Wistar recipients of kidney from SHR were compared to data from transplanted Wistar submitted to CsA treatment and, to Wistar Sham. Results and Discussion: Despite the unaltered blood pressure observed at early stages, 80/90-kDa ACE was found expressed in the urine of rats 7 and 15 days after transplantation, which was intense when rats became hypertensive 30 days post-surgery. Conclusion: Our data show that this enzyme is associated with the development of hypertension, and this marker appears in the urine before any substantial blood pressure alteration.
Subject: Hypertension
Kidney Transplantation
Renin-angiotensin System
Sistema Renina-angiotensina
Transplante De Rim
Editor: Sociedade Brasileira de Nefrologia
Citation: Jornal Brasileiro De Nefrologia. Sociedade Brasileira De Nefrologia, v. 39, n. 1, p. 11 - 14
Rights: aberto
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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