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Type: Artigo
Title: Hypothalamic Endoplasmic Reticulum Stress Of Overtrained Mice After Recovery
Author: Pinto
Ana P.; Oliveira
Luciana da C.; Rocha
Alisson L. da; Pereira
Bruno C.; Morais
Gustavo P.; Vicente
Larissa Gaioto de; Moura
Leandro P.; Pauli
José R.; Silva
Adelino S. R. da
Abstract: knowing the relationship between endoplasmic reticulum (ER) stress and inflammation and based on the fact that downhill running-based overtraining (OT) model increases hypothalamus levels of some pro-inflammatory cytokines, we verified the effects of three OT protocols on the levels of BiP, pIRE-1 (Ser734), pPERK (Thr981), pelF2alpha (Ser52), ATF-6 and GRP-94 proteins in the mouse hypothalamus after two weeks of recovery. METHODS the mice were randomized into control (CT), overtrained by downhill running (OTR/down), overtrained by uphill running (OTR/up) and overtrained by running without inclination (OTR) groups. After 2-week total recovery period (i.e., week 10), hypothalamus was removed and used for immunoblotting. RESULTS the OTR/down group exhibited high levels of BiP and ATF6. The other OT protocols showed higher levels of pPERK (Th981) and pelf-2alpha (Ser52) when compared with the CT group. CONCLUSION the current results suggest that after a 2-week total recovery period, the overtrained groups increased partially their ER stress protein levels, but without hypothalamic inflammation, which characterizes a physiological condition related to an adaptation mechanism.
Subject: Er Stress
Overtraining Protocols, Hypothalamus, Inflammation
Editor: Universidade Estadual Paulista
Rights: aberto
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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