Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/324821
Type: Artigo
Title: Molecular Mechanisms Of Glucose Uptake In Skeletal Muscle At Rest And In Response To Exercise
Author: Pereira
Rodrigo Martins; Moura
Leandro Pereira de; Muñoz
Vitor Rosetto; Silva
Adelino Sanchez Ramos da; Gaspar
Rodrigo Stellzer; Ropelle
Eduardo Rochete; Pauli
José Rodrigo
Abstract: Glucose uptake is an important phenomenon for cell homeostasis and for organism health. Under resting conditions, skeletal muscle is dependent on insulin to promote glucose uptake.Insulin, after binding to its membrane receptor, triggers a cascade of intracellular reactions culminating in activation of the glucose transporter 4, GLUT4, among other outcomes.This transporter migrates to the plasma membrane and assists in glucose internalization.However, under special conditions such as physical exercise, alterations in the levels of intracellular molecules such as ATP and calcium actto regulate GLUT4 translocation and glucose uptake in skeletal muscle, regardless of insulinlevels.Regular physical exercise, due to stimulating pathways related to glucose uptake, is an important non-pharmacological intervention for improving glycemic control in obese and diabetic patients. In this mini-review the main mechanisms involved in glucose uptake in skeletal muscle in response to muscle contraction will be investigated.
Subject: Exercise
Skeletal Muscle
Glucose Uptake
Glut4
Editor: Universidade Estadual Paulista
Rights: aberto
Address: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-65742017000500202&lng=en&tlng=en
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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