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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigopt_BR
dc.titleCromatografia Por Interações Hidrofilicas (hilic): Estado Da Arte E Aplicaçõesen
dc.title.alternativeHydrophilic Interaction Chromatography (hilic): State Of The Art And Applicationspt_BR
dc.contributor.authorSilvapt_BR
dc.contributor.authorCarla Grazieli Azevedo da; Bottolipt_BR
dc.contributor.authorCarla Beatriz Grespan; Collinspt_BR
dc.contributor.authorCarol H.pt_BR
unicamp.authorUniversidade Estadual de Campinas Instituto de Química, Campinas SP, Brazilpt_BR
dc.subjectHydrophilic Interaction Chromatographyen
dc.subjectSeparation Of Polar Compoundsen
dc.subjectHilic Separationsen
dc.subjectHigh Performance Liquid Chromatographyen
dc.subjectPolar Stationary Phasesen
dc.description.abstractHydrophilic interaction liquid chromatography (HILIC) has been gaining increased attention for its effective separation of highly polar compounds, which include carbohydrates, amino acids, pharmaceutical compounds, proteins, glycoproteins, nucleosides, etc. Polar compounds are usually poorly retained on reverse-phase liquid chromatography (RP-HPLC) columns or have poor solubility in the apolar mobile phase of normal-phase high performance liquid chromatography (NP-HPLC). Since HILIC uses organic solvents such as ACN or MeOH ( > 70%), also used in RP-HPLC and polar stationary phases similar to NP-HPLC (bare silica, diol, amino, amide, saccharide, zwitterionic stationary phases, etc.), it represents a hybrid of the two separation modes. The high organic content in the MP leads to good compatibility with mass spectrometry (MS), increasing the detectivity. This review describes the fundamentals of HILIC and highlights some interesting applications.en
dc.relation.ispartofQuímica Novapt_BR
dc.publisherSociedade Brasileira de Químicapt_BR
dc.date.issued2016pt_BR
dc.identifier.citationQuímica Nova. Sociedade Brasileira De Química, v. 39, n. 2, p. 210 - 220pt_BR
dc.language.isoPortuguêspt_BR
dc.description.volume39pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage210pt_BR
dc.description.lastpage220pt_BR
dc.rightsabertopt_BR
dc.sourceScielopt_BR
dc.identifier.issn0100-4042pt_BR
dc.identifier.idScieloS0100-40422016000200210pt_BR
dc.identifier.urlhttp://www.scielo.br/scielo.php?pid=S0100-40422016000200210&script=sci_abstractpt_BR
dc.date.available2017-08-30T17:37:33Z-
dc.date.accessioned2017-08-30T17:37:33Z-
dc.description.provenanceMade available in DSpace on 2017-08-30T17:37:33Z (GMT). No. of bitstreams: 1 S0100-40422016000200210.pdf: 3144894 bytes, checksum: c90190615230ae8b6cd841d8fd2a7af7 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/324817-
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