Please use this identifier to cite or link to this item:
Type: Artigo
Title: Sweat Test And Cystic Fibrosis: Overview Of Test Performance At Public And Private Centers In The State Of São Paulo, Brazil
Title Alternative: Teste Do Suor E Fibrose Cística: Panorama Da Realização Do Teste Em Centros Públicos E Privados Do Estado De São Paulo
Author: Servidoni
Maria Fátima; Gomez
Carla Cristina Souza; Marson
Fernando Augusto Lima; Toro
Adyléia Aparecida Dalbo Contrera; Ribeiro
Maria Ângela Gonçalves de Oliveira; Ribeiro
José Dirceu; Ribeiro
Antônio Fernando
Abstract: The sweat test (ST) measures chloride levels in sweat and is considered the gold standard for the diagnosis of cystic fibrosis (CF). However, the reliability of a ST depends on their being performed by experienced technicians and in accordance with strict guidelines. Our aim was to evaluate how sweat stimulation, sweat collection, and chloride measurement are performed at 14 centers (9 public centers and 5 private centers) that routinely perform STs in the state of São Paulo, which has the highest frequency of CF in Brazil. Methods: This was a cross-sectional cohort study, using a standardized questionnaire administered in loco to the staff responsible for conducting STs. Results: No uniformity regarding the procedures was found among the centers. Most centers were noncompliant with the international guidelines, especially regarding the collection of sweat (the samples were insufficient in 10-50% of the subjects tested); availability of stimulation equipment (which was limited at 2 centers); modernity and certification of stimulation equipment (most of the equipment having been used for 3-23 years); and written protocols (which were lacking at 12 centers). Knowledge of ST guidelines was evaluated at only 1 center. Conclusions: Our results show that STs largely deviate from internationally accepted guidelines at the participating centers. Therefore, there is an urgent need for standardization of STs, training of qualified personnel, and acquisition/certification of suitable equipment. These are essential conditions for a reliable diagnosis of CF, especially with the increasing demand due to newborn screening nationwide, and for the assessment of a possible clinical benefit from the use of modulator drugs.
Subject: Cystic Fibrosis/diagnosis
Cystic Fibrosis/prevention & Control
Fibrose Cística/diagnóstico
Fibrose Cística/prevenção & Controle
Editor: Sociedade Brasileira de Pneumologia e Tisiologia
Rights: aberto
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
S1806-37132017000200121por.pdf460.8 kBAdobe PDFView/Open
S1806-37132017000200121eng.pdf449.58 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.